Center for Molecular Spectroscopy and Dynamics

    IBS Center for Molecular Spectroscopy and Dynamics

n  SPEAKER
Prof. Min Ju Shon (POSTECH)

n  TITLE
High-speed tracking of synaptic protein interactions

n  ABSTRACT
Molecular observations of synaptic proteins provide a unique viewpoint on neurotransmission that complements electrophysiology measurements. In this talk, I will introduce molecular tweezers that can monitor the zippering of single SNARE complexes, a process that drives synaptic vesicle fusion. Using a magnetic particle, the method simultaneously manipulates and probes the structure of a SNARE complex with a millisecond time resolution, revealing partially zippered SNAREs and their interactions with other presynaptic proteins. We found that distinct intermediate forms of a SNARE complex are differentially regulated by associated proteins. Overall, these observations highlight the significance of high-resolution measurements of subtle structural changes in biomolecular complexes, and how such force application techniques can be employed to address mechanical aspects of molecular neuroscience.

n  DATE AND VENUE
August 02, 2022 (Tuesday, 11:00 - 12:00)  

Seminar Room A (116)

n  LANGUAGE
Korean

n  INVITED BY
Prof. Seok-Cheol Hong