Center for Relativistic Laser Science

2019 SPIE Photonics West

Abstract: Optical imaging with diffraction-limited resolution has been a challenging task for targets deep within strongly scattering, inhomogeneous media such as biological tissues. Obtaining high-resolution images through inhomogeneous media is severely hindered not only by the background noise from multiple scattering of light but also by sample-induced aberration. To extend the imaging depth while maintaining a diffraction-limited resolution, we present here an improved high-resolution adaptive optical imaging method having a high single-to-multiple scattering ratio (SMR). The method is based on the CLASS microscopy [Nature Comm. 8, 2157 (2017)], but it uses point illumination which gives up to 10,000 times improved SMR and a two-times deeper maximum imaging depth than that of original CLASS.