IBS Institute for Basic Science

IBS CMSD Seminar_Prof. Yongdae Shin(Seoul National University)(Aug 21, 2019)

작성자 : Center for Molecular Spectroscopy and Dynamics 등록일 : 2019-08-14 조회수:835


      IBS Center for Molecular Spectroscopy and Dynamics









Prof. Yongdae Shin (Dep. Of Mechanical Engineering, Seoul National Uni.)

Using light to control phase separation in living cells

   The cell is compartmentalized with numerous organelles that facilitate spatio-temporal regulation of biological reactions. Cellular organelles are not limited to canonical membrane-bound structures such as nucleus and mitochondria but include membrane-less assemblies – for example, nucleoli, nuclear speckles and Cajal bodies in nucleus and cytoplasmic stress/germ granules. Emerging evidence suggests that membrane-less structures represent mesoscale liquid-like droplets surrounded by coexisting nucleo/cytoplasm, which form through liquid-liquid phase separation. An aberrant transition from a liquid-like state into solid aggregates is thought to underlie the pathogenesis of several neurodegenerative diseases. In this talk, I will discuss a series of efforts aiming to develop novel optogenetic technologies that enable the control of intracellular phases. Using these tools, a relation between different material states (liquid vs solid) has been examined and physical parameters shaping localized phase separation are probed. A recent version of the optogenetic approach combines genomic targeting with phase separating modules, revealing an interesting mechanical interplay between phase-separated liquids and surrounding genome. Together, these approaches open a new opportunity to navigate intracellular phase space which is central to the basic biology of cellular organization as well as the onset of protein condensation diseases.

 August 21, 2019 (Wednesday, 11:00 - 12:00)  

Seminar Room A (116), KU R&D Center

        INVITED BY
Professor Sang-Hee Shim