IBS Institute for Basic Science

IBS-CMSD Colloquium_Prof. Ryota Iino(National Institutes of Natural Sciences, Japan)(Apr. 24, 2018)

작성자 : Center for Molecular Spectroscopy and Dynamics 등록일 : 2018-04-04 조회수:1406

    IBS Center for Molecular Spectroscopy and Dynamics





Prof. Ryota Iino (Institute for Molecular Science, National Institutes of Natural Sciences, Japan)

High-speed single-molecule imaging analysis of protein molecular motors with plasmonic nanoprobes

We have been developing high-speed single-molecule imaging methods monitoring fast motions of protein molecular motors with nanometer localization precision and microsecond temporal resolution [1]. Our methods are based on dark-field scattering imaging of plasmonic nanoprobes such as gold nanoparticles [2] and nanorods [3]. As probes of single-molecule imaging, the plasmonic nanoprobes have advantages over the commonly used ones such as fluorescent dyes and quantum dots, because much stronger signals can be obtained without suffering from photobleaching and blinking. In this seminar, I will discuss the mechanisms of chemo-mechanical coupling, unidirectionality, and coordination of linear molecular motors kinesin-1 [4] and chitinase, and rotary molecular motors F1-ATPase and V1-ATPase [5-7], revealed by our high-speed single-molecule imaging analysis. I will also introduce our recent approaches to achieve angstrom-level localization precision and multi-color imaging with plasmonic nanoprobes.

  April 24, 2018 (Tuesday, 4:00 - 5:00 pm)  

Seminar Room 116, KU R&D Center



        INVITED BY
Prof. Seok-Cheol Hong


      *If you want to have dinner with Prof. Ryota Iino or discuss with him, please contact Prof.              Seok-Cheol Hong (hongsc@korea.ac.kr).