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IBS-CMSD Colloquium_Prof. Jie Yan(National Uni. of Singapore)(Nov. 10)

작성자 : Center for Molecular Spectroscopy and Dynamics 등록일 : 2017-11-10 조회수:6917


      IBS Center for Molecular Spectroscopy and Dynamics

 

COLLOQUIUM

 

 

        SPEAKER
Prof. Jie Yan (Mechanobiology Institute, National Uni. of Singapore)


        TITLE
Formins sense both force and torque during formin-dependent actin filament polymerization


        ABSTRACT
Formins, an important family of force-bearing actin-polymerizing factors, function as homodimers that bind the barbed end of actin filaments through a ring-like structure assembled from dimerized FH2 domains. In this work, we used transverse magnetic tweezers [1] to apply force to a single formin attached to a single actin filament. We found that physiological level of forces could drastically speed up the actin polymerization rate. Further, we found that this force-promoted actin polymerization required torsionally unconstrained actin filament, suggesting that formins also sense torque in the actin filament [2]. As actin filaments are subject to complex dynamic mechanical constraints in living cells, these results provide important insights into how formin/profilin-mediated actin polymerization is regulated by these mechanical constraints.


        DATE AND VENUE
November 10, 2017 (Friday, 4:00 - 5:00 pm)  

Seminar Room 116, KU R&D Center


        LANGUAGE
English


        INVITED BY
Prof. Seok-Cheol Hong


 *If you want to have dinner with Prof. Jie Yan, please contact to Prof. Seok-Cheol Hong(hong1sc@gmail.com)